Mast cell-fibroblast interactions induce matrix metalloproteinase-9 release from fibroblasts: role for IgE-mediated mast cell activation.

Activation Fibroblasts: Role for IgE-Mediated Mast Cell Matrix Metalloproteinase-9 Release from Mast Cell-Fibroblast Interactions Induce

IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes.

BACKGROUND IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whet...

Anaphylaxis is a serious immediate allergic reaction that involves the activation of mast cells. Cross-linking of the high-affinity IgE receptor FcεRI on mast cells with IgE and antigen initiates signals

Anaphylaxis is a serious immediate allergic reaction that involves the activation of mast cells. Cross-linking of the high-affinity IgE receptor FcεRI on mast cells with IgE and antigen initiates signals leading to the release of allergic mediators that induce immediate hypersensitivity1. Anaphylaxis is triggered by allergens (for example, insect venom, food and medication) and damages multiple...

Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha

Chronic allergic diseases and other disorders associated with mast cell activation can also be associated with tissue fibrosis, but a direct link between mast cell mediator release and fibroblast collagen gene expression has not been established. Using in situ hybridization, we show that the elicitation of an IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice results in a transi...

Matrix metalloproteinase-9 production, a newly identified function of mast cell progenitors, is downregulated by c-kit receptor activation.

Mast cell precursors invade from the peripheral blood into local tissues where they differentiate to their mature phenotypes. However, the mechanism of this migration process has been unclear. We clearly demonstrated here the production and release of matrix metalloproteinase-9 (MMP-9), a matrix-degrading enzyme necessary for leukocyte transmigration, by interleukin-3-dependent mouse mast cell ...